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We think GLP-1s may shut down the ability for stem cells in dermal white adipose tissue, a thin layer of fat beneath the skin, to signal fibroblasts to produce collagen and elastin, says Steven Dayan, MD, a plastic surgeon in Chicago who has co-authored research papers on GLP-1s aesthetic side effects

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This highlights a theme: cinnamon compounds often work by modulating endogenous GPCR ligands (hormones/neurotransmitters) rather than binding GPCRs in a lock-and-key fashion themselves

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